Spanlastic-Laden Nanogel for Dermal Delivery of Bimatoprost in Androgenic Alopecia

    March 2024 in “ International journal of pharmaceutics. X ”
    Bjad K. Almutairy, El-Sayed Khafagy, Mohammed F. Aldawsari … Amr S. Abu Lila
    Studysummary This study explored the use of spanlastic vesicles to enhance the delivery of bimatoprost for treating alopecia and found that a bimatoprost-loaded nanogel significantly increased skin drug accumulation and improved hair regrowth in a mouse model, outperforming both naive bimatoprost gel and commercial minoxidil formulations.
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    Research cited in this study 13

    1. Formulation Optimization, In Vitro and In Vivo Evaluation of Niosomal Nanocarriers for Enhanced Topical Delivery of Cetirizine Saudi Pharmaceutical Journal · 2023
    2. The Efficacy of Topical Prostaglandin Analogs for Hair Loss: A Systematic Review and Meta-Analysis Frontiers in Medicine · 2023
    3. Topical Cetirizine for Treating Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    4. Preparation of Topical Bimatoprost with Enhanced Skin Infiltration and In Vivo Hair Regrowth Efficacy in Androgenic Alopecia Drug Delivery · 2022
    5. Alleviation of Androgenetic Alopecia with Aqueous Paeonia Lactiflora and Poria Cocos Extract Intake Through Suppressing the Steroid Hormone and Inflammatory Pathway Pharmaceuticals · 2021
    6. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    7. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    8. The Effectiveness of 0.03% Bimatoprost Solution vs Minoxidil 5% in Androgenic Alopecia Indian Journal of Public Health Research and Development · 2018
    9. Bimatoprost for the Treatment of Eyelash, Eyebrow, and Scalp Alopecia Expert Opinion on Investigational Drugs · 2017
    10. No Genetic Support for a Contribution of Prostaglandins to the Etiology of Androgenetic Alopecia British Journal of Dermatology · 2013
    11. Liposomal Systems as Drug Delivery Vehicles for Dermal and Transdermal Applications Archives of Dermatological Research · 2011
    12. Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash Growth Dermatologic Surgery · 2010
    13. Bimatoprost in the Treatment of Eyelash Hypotrichosis Clinical ophthalmology · 2010