Evaluation of Topical Sodium Valproate-Loaded Nano Spanlastics Formulation Versus Minoxidil 5% in the Treatment of Female Pattern Hair Loss Using Transdermal Delivery: A Comparative Study
January 2023
in “
The Egyptian Journal of Hospital Medicine
”
Studysummary This study found that topical valproic acid and 5% minoxidil both significantly increased hair count in patients with female pattern hair loss, suggesting topical valproic acid as a potential treatment option.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study evaluated the effectiveness of topical Valproic acid (VPA) and 5% topical minoxidil in treating Female Pattern Hair Loss (FPHL). It included 81 patients with FPHL, divided into three groups: 27 treated with topical sodium valproate-loaded nano spanlastics formulation, 27 treated with minoxidil® 5% lotion, and 27 treated with saline using transdermal delivery for 6 months. The results showed that both VPA and minoxidil significantly increased the total hair count compared to the control group (P = 0.047). Adverse events were moderate and self-limiting in both groups, with comparable prevalence rates (P = 0.72). The study concluded that topical VPA is a potential therapy option for FPHL.
