Vitamin E TPGS Based Transferosomes Augmented TAT as a Promising Delivery System for Improved Transdermal Delivery of Raloxifene

    December 2019 in “ PLoS ONE ”
    Nabil A. Alhakamy, Usama A. Fahmy, Osama A. A. Ahmed
    TLDR The new delivery system improved raloxifene's skin absorption and effectiveness against cancer cells.
    The study aimed to improve the bioavailability of raloxifene, commonly used for breast cancer protection, by enhancing its solubility and cellular penetration. Researchers formulated D-α-tocopheryl polyethylene glycol 1000 succinate-based transferosomes, augmented with the cationic cell-penetrating peptide transactivator of transcription from the human immunodeficiency virus. These nano-lipid carriers, characterized by an average vesicle size of 96.05 nm and a zeta potential of 39.4 mV, significantly enhanced raloxifene permeation through rat skin and improved cytotoxicity against MCF-7 cell lines by 1.42-fold compared to raw raloxifene. The developed transferosomes were considered promising for enhancing raloxifene delivery.
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