TLDR Minoxidil dissolves better in propylene glycol + water than in supercritical CO2.
This study investigated the solubility of Minoxidil, an antihypertensive drug, in supercritical carbon dioxide (SC-CO2) under different conditions. The study found that the solubility of Minoxidil increased with pressure under isothermal conditions, and the highest and lowest solubilities were achieved at 338 K, 270 bar and 328 K, 120 bar, respectively. The study also compared the solubility of Minoxidil in different solvents and found that it was higher in propylene glycol + water binary system than in SC-CO2. The study provides important information for the development of new drug delivery systems using supercritical CO2.
7 citations,
February 2019 in “Journal of Molecular Liquids” Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.
24 citations,
May 2013 in “Drug Design Development and Therapy” Multimodal minoxidil microemulsion is more effective in treating hair loss than minoxidil alone.
24 citations,
April 2011 in “Journal of Chemical & Engineering Data” Minoxidil dissolves best in methanol and least in water.
66 citations,
February 2010 in “CrystEngComm” Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
397 citations,
February 2004 in “British Journal of Dermatology” Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.
63 citations,
September 1987 in “Journal of Biological Chemistry” Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
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July 2017 in “Archives of Dermatological Research” Herbal products might promote hair growth with fewer side effects, but more research is needed to confirm their safety and effectiveness.
96 citations,
September 2021 in “International Journal of Molecular Sciences” Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.
Hair RiseTM microemulsion effectively promotes hair growth and treats hair loss better than standard treatments.
May 2024 in “Molecules/Molecules online/Molecules annual” Plant extracts can help prevent hair loss and promote hair growth.
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