Experimental and Thermodynamic Analyses of Supercritical CO2 Solubility of Minoxidil as an Antihypertensive Drug

    November 2020 in “ Fluid Phase Equilibria ”
    Gholamhossein Sodeifian, Nedasadat Saadati Ardestani, Fariba Razmimanesh, Gholamhossein Sodeifian
    Studysummary In this study, researchers measured the solubility of Minoxidil in supercritical CO₂ under various temperature and pressure conditions and created models to estimate solubility based on different predictive approaches.
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    Research cited in this study 7

    1. Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures Journal of Molecular Liquids · 2019
    2. Preparation and Evaluation of a Multimodal Minoxidil Microemulsion Versus Minoxidil Alone in the Treatment of Androgenic Alopecia of Mixed Etiology: A Pilot Study Drug Design Development and Therapy · 2013
    3. Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K Journal of Chemical & Engineering Data · 2011
    4. Attempted Construction of Minoxidil: Carboxylic Acid Cocrystals; 7 Salts and 1 Cocrystal Resulted CrystEngComm · 2010
    5. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    6. Effects of Hypertrichotic Agents on Follicular and Nonfollicular Cells In Vitro Skin Pharmacology and Physiology · 1996
    7. Suppression of Fibroblast Proliferation and Lysyl Hydroxylase Activity by Minoxidil Journal of Biological Chemistry · 1987