Attempted Construction of Minoxidil: Carboxylic Acid Cocrystals; 7 Salts and 1 Cocrystal Resulted

    February 2010 in “ CrystEngComm ”
    Nate Schultheiss, Keith R. Lorimer, Skylar Wolfe, John Desper
    Image of study
    TLDR Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
    This document describes attempts to create cocrystals of minoxidil with carboxylic acids. The researchers successfully generated eight multi-component samples, which were analyzed by single-crystal X-ray diffraction revealing the formation of one cocrystal and seven salts. The study found that the carboxylate/N-hydroxide synthon or its neutral analog proved to be a robust supramolecular interaction, while the amino-pyridine and piperidine moieties failed to participate within this molecular arrangement. The study concludes that further understanding of competing intermolecular interactions is necessary to design and produce multimeric products with anticipated connectivities and stoichiometries.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Minoxidil and Finastride topical solution 2 months update

      in Minoxidil  6 upvotes 6 days ago
      A 34-year-old woman has been using a topical solution of 5% Minoxidil and 0.1% Finasteride since January 2026 to address hair thinning caused by PCOS and poor nutrition. She reports ongoing hair shedding but has improved her diet with whole foods and supplements.

      community Hair partition and Minoxidil Application

      in Minoxidil  2 upvotes 1 week ago
      A user is experiencing hair loss and is using Morr F 5% Minoxidil, Finasteride Lipid Solution, ketoconazole shampoo, and biotin tablets. They seek advice on the correct application method and hair partitioning.

      community Minoxidil asking advice as an 23F

      in Minoxidil  1 upvotes 2 weeks ago
      A 23-year-old woman is considering starting minoxidil for hair thinning but is concerned about its long-term use and effectiveness. Recommendations include consulting a doctor, checking ferritin levels, and considering treatments like spironolactone or finasteride, while minoxidil is suggested for regrowth but not as a primary treatment.

      community Using minoxidil for 6 months. Not seeing results

      in Minoxidil  111 upvotes 2 weeks ago
      Minoxidil alone is not effective for hair regrowth; adding a DHT blocker like finasteride or dutasteride is recommended. Dermastamping and micro-needling can enhance results, and some users suggest trying oral minoxidil or natural DHT blockers.

    Related Research

    1 / 1 results