Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

February 2019 in “ Journal of Molecular Liquids ”

Faezeh H. Pirhayati, Shahla Mirzaeei, Elaheh Rahimpour, Ghobad Mohammadi, Fleming Martínez, Shiva Taghe, Abolghasem Jouyban

minoxidil propylene glycol water mixtures solubility endothermic entropically favorable cosolvency models Jouyban-Acree-van't Hoff model Rogaine PG

TLDR Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.

The study from April 1, 2019, focused on the solubility of minoxidil in propylene glycol (PG) and water mixtures across temperatures from 293.2 K to 313.2 K. It was found that minoxidil solubility increased with the mass fraction of PG and temperature, peaking in pure PG at 313.2 K. The dissolution process was determined to be endothermic and entropically favorable, though not spontaneous. Minoxidil showed preferential solvation by water in water-rich mixtures and by PG when the PG mass fraction exceeded 0.19. The study utilized four cosolvency models to correlate the solubility data, with the Jouyban-Acree-van't Hoff model providing the most accurate predictions, as indicated by mean relative deviations (MRD%). The research, supported by a grant from the School of Pharmacy at Kermanshah University of Medical Sciences, offers valuable insights for pharmaceutical formulations of minoxidil.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Solubility of Minoxidil in Binary Mixture of Ethanol and Water at Various Temperatures

20 citations, October 2018 in “Physics and chemistry of liquids”

Minoxidil dissolves better in ethanol-water mixtures at different temperatures, with water playing a key role.

Intestinal Permeability Study of Minoxidil: Assessment of Minoxidil as a High Permeability Reference Drug for Biopharmaceutics Classification

research Intestinal Permeability Study of Minoxidil: Assessment of Minoxidil as a High Permeability Reference Drug for Biopharmaceutics Classification

13 citations, January 2015 in “Molecular Pharmaceutics”

Minoxidil works well as a high permeability reference drug for biopharmaceutics classification.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

24 citations, April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

Development and Validation of a Procedure for the Determination of Minoxidil in Hair-Regrowth Formulations Using Two Variants of Capillary Zone Electrophoresis

research Development and Validation of a Procedure for the Determination of Minoxidil in Hair-Regrowth Formulations Using Two Variants of Capillary Zone Electrophoresis

14 citations, May 2005 in “Farmaco”

A method was created in 2005 to identify minoxidil, a hair growth ingredient, in products using two types of capillary zone electrophoresis, and it found that most products had about 2% minoxidil.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

Related Research

1 / 1 results

Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

research Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

7 citations, February 2019 in “Journal of Molecular Liquids”

Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.

Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

Research cited in this study

research Solubility of Minoxidil in Binary Mixture of Ethanol and Water at Various Temperatures

research Intestinal Permeability Study of Minoxidil: Assessment of Minoxidil as a High Permeability Reference Drug for Biopharmaceutics Classification

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

research Development and Validation of a Procedure for the Determination of Minoxidil in Hair-Regrowth Formulations Using Two Variants of Capillary Zone Electrophoresis

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

Related Community Posts Join

community Creating Your Own Topicals: A Guide

community Sandalore: a scientific homemade approch

community Homemade finasteride foam similar to minoxidil foam

community Is it ok to mix minoxidil solution with bottled water instead of distilled water?

community drinking topical minoxidil – extreme hair growth everywhere

community 32, Southeast Asian, 1 y 3 m Finasteride, Dutasteride, Minoxidil, Microneedling – Former hair system user. Quick description of routine in comments.

Related Research

research Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures