Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

    April 2011 in “ Journal of Chemical & Engineering Data ”
    Hao Yan, Runyan Li, Qiang Li, Jingkang Wang, Junbo Gong
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    TLDR Minoxidil dissolves best in methanol and least in water.
    This study measured the solubility of minoxidil in six solvents at different temperatures using a gravimetric method. The data was well-correlated using the Apelblat equation. The mole fraction solubility of minoxidil was found to decrease in the order of methanol > 1-propanol > 1-butanol > ethanol > 2-propanol > water at the same temperature. The results are important for drug discovery and preparation stages, as well as for the design of an optimized crystallization process.
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