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Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

research Experimental and computational approaches for measuring minoxidil solubility in propylene glycol + water mixtures at different temperatures

7 citations , February 2019 in “Journal of Molecular Liquids”

This study assessed minoxidil solubility in propylene glycol and water mixtures, comparing cosolvency models and examining thermodynamic properties, without reporting new clinical results.

Solubility of Minoxidil in Binary Mixture of Ethanol and Water at Various Temperatures

research Solubility of minoxidil in binary mixture of ethanol + water at various temperatures

20 citations , October 2018 in “Physics and chemistry of liquids”

This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.

research Increasing the solubility of minoxidil using a mixture of 1-propanol and water by the shake flask method: experimental measurements, thermodynamic analyses, and mathematical modeling

December 2025 in “Brazilian Journal of Chemical Engineering”

research Effect of oil, water and surfactant mixture on the physicochemical properties and transdermal delivery of finasteride-loaded microemulsions: evaluation and prediction using response surface methodology

January 2017 in “Isan Journal of Pharmaceutical Sciences”

This study explored microemulsion formulations for delivering finasteride through the skin, finding that higher water concentrations increased permeation, which may inform optimal transdermal delivery for treating androgenetic alopecia.

research In vitro and in vivo study of dye diffusion into the human skin and hair follicles

69 citations , January 2002 in “Journal of biomedical optics”

This study found that commercially available dyes penetrate up to 1.2 mm into human skin, with Indocyanine Green binding to cell proteins and showing a shift in absorption peak.

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community Diluting DIY topical finasteride

2 upvotes 1 year ago

A user is discussing making a DIY topical finasteride solution using ingredients like water, alcohol, propylene glycol, ethanol, and glycerin, and is concerned about the stability of the mixture. Other users suggest that the solution will work and discuss the importance of propylene glycol for drug dissolution and factors like temperature and light affecting finasteride stability.

community Topical finasteride making. Powder not disolving

4 upvotes 3 years ago

OP is trying to dissolve finasteride powder for a topical solution but faces issues with it not dissolving properly in ethanol or water. Users suggest methods like using a magnetic stirrer, shaking the mixture, or filtering out fillers, with some noting that finasteride is soluble in alcohol.

community How can I make topical fin that stays on my scalp?

1 upvotes 4 months ago

A user is making a topical finasteride solution with 0.01% finasteride, 50% ethanol, 15% glycerine, and 35% water, but it doesn't adhere well to the scalp. They seek advice on improving the mixture's consistency without taking oral pills.

community Mixing Stemoxydine 5% with premixed solution of RU58841 5%

2 upvotes 2 years ago

The user is using Dutasteride, Nizoral, and RU58841 for hair loss and is considering mixing RU58841 with Stemoxydine for better scalp coverage but is concerned about the potential degradation of RU58841 when mixed with a water-based solution. They are seeking advice on the feasibility of this mixture.

community RU58841 mixing with water solution

5 upvotes 4 years ago

RU58841 is being mixed with Minoxidil solution, but concerns arise about water causing instability. Mixing with water may lead to hydrolysis, potentially reducing effectiveness.

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