Increasing the Solubility of Minoxidil Using a Mixture of 1-Propanol and Water by the Shake Flask Method: Experimental Measurements, Thermodynamic Analyses, and Mathematical Modeling

December 2025 in “ Brazilian Journal of Chemical Engineering ”

Esmaeil Mohammadian, Amir Mohammad Ahmadi, Mahmoud Omidi, Fleming Martinez, Seyyed Mohammad Hassan Hashemi

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research Minoxidil: A Comprehensive Review

16 citations , June 2021 in “Journal of Dermatological Treatment”

This study reported that while topical minoxidil exhibits hair regrowth in androgenetic alopecia, oral minoxidil 5 mg/day was more effective than topical forms after six months, with low doses also potentially effective for women and other hair loss types.

Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

research Efficacy and Safety of a New 10% Topical Minoxidil Versus 5% Topical Minoxidil and Placebo in the Treatment of Male Androgenetic Alopecia: A Trichoscopic Evaluation

14 citations , August 2019 in “Journal of Dermatological Treatment”

This study found that 5% topical minoxidil was moderately more effective at increasing hair regrowth than 10% minoxidil and placebo in men with androgenetic alopecia.

Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

research Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

7 citations , February 2019 in “Journal of Molecular Liquids”

This study assessed minoxidil solubility in propylene glycol and water mixtures, comparing cosolvency models and examining thermodynamic properties, without reporting new clinical results.

research Solubility of Minoxidil in Binary Mixture of Ethanol and Water at Various Temperatures

20 citations , October 2018 in “Physics and chemistry of liquids”

This study found that minoxidil exhibits preferential solvation by water in both water-rich and ethanol-rich solvent mixtures.

research Minoxidil Use in Dermatology, Side Effects, and Recent Patents

152 citations , April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

This review describes minoxidil's hair regrowth mechanism and discusses dermatological applications, but reports no new clinical results, emphasizing the need for regular use and addressing allergic reactions.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

24 citations , April 2011 in “Journal of Chemical & Engineering Data”

This study measured the solubility of minoxidil in various solvents, finding the highest solubility in methanol and lowest in water, with solubility correlating to temperature.

Development and Validation of a Procedure for the Determination of Minoxidil in Hair-Regrowth Formulations Using Two Variants of Capillary Zone Electrophoresis

research Development and Validation of a Procedure for the Determination of Minoxidil in Hair-Regrowth Formulations Using Two Variants of Capillary Zone Electrophoresis

14 citations , May 2005 in “Farmaco”

This study developed a high performance capillary electrophoresis method, validated for both legal and illicit minoxidil-based products, to confirm minoxidil's presence alongside known impurities.