Androgenic Alopecia: Recent Understanding of the Androgenetic Receptor-Mediated Molecular Mechanisms and Current Pharmacotherapy

    Preeti K. Suresh, Shweta Ramkar
    TLDR Androgenic alopecia is mainly caused by DHT, and new treatments focus on hair regeneration and aging factors.
    Androgenic alopecia (AGA) is primarily caused by dihydrotestosterone (DHT), which is produced from testosterone by the 5a-reductase enzyme, leading to a characteristic pattern of hair loss. The review delves into the molecular mechanisms of AGA, emphasizing the role of follicular stem cells in hair regeneration and the impact of aging factors. It also examines recent advancements in pharmacotherapy, offering insights into potential treatment options for AGA.
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