Faculty Opinions Recommendation of Topical Valproic Acid Increases the Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

    July 2014 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Juan Ferrando, José M Mir-Bonafé
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    TLDR Applying valproic acid on the scalp increased hair growth in men with hair loss.
    In a study conducted 9 years ago, the anticonvulsant valproic acid (VPA) was topically tested on 27 male patients with androgenetic alopecia (AGA). The study was based on the hypothesis that VPA inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway. The results showed that VPA was superior to a placebo in increasing total hair count, as determined by phototrichogram analysis. This suggested that topical VPA could potentially be a new therapeutic approach for men with AGA.
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      in Treatment  4 upvotes 4 years ago
      The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

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      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

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      in Question  2 upvotes 6 years ago
      The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

      community New & Improved Hair Growth Stack for Maximum Results

      in Treatment  2 upvotes 3 weeks ago
      A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

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