Faculty Opinions Recommendation of Topical Valproic Acid Increases the Hair Count in Male Patients with Androgenetic Alopecia: A Randomized, Comparative, Clinical Feasibility Study Using Phototrichogram Analysis

    July 2014 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”
    Juan Ferrando, José M Mir-Bonafé
    Image of study
    TLDR Applying valproic acid on the scalp increased hair growth in men with hair loss.
    In a study conducted 9 years ago, the anticonvulsant valproic acid (VPA) was topically tested on 27 male patients with androgenetic alopecia (AGA). The study was based on the hypothesis that VPA inhibits glycogen synthase kinase 3β and activates the Wnt/β-catenin pathway. The results showed that VPA was superior to a placebo in increasing total hair count, as determined by phototrichogram analysis. This suggested that topical VPA could potentially be a new therapeutic approach for men with AGA.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 9 results

      community Here is my hair regrowth plan

      in Treatment  3 upvotes 3 years ago
      The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 3 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Topical VPA - Anyone experiences here?

      in Question  2 upvotes 6 years ago
      The conversation is about using topical valproic acid (VPA) for hair loss, focusing on its application method, usage frequency, and combination with other treatments like micro-needling. No specific experiences with VPA were shared.

      community Figuring out my own experimental protocol

      in Treatment  10 upvotes 1 year ago
      User tries dermapen for hair loss and plans to use non-mainstream topicals like c60, ghk-cu, and ptd-dbm with valproic acid. They also use a head massager and modified LLLT belt for additional treatment.

    Related Research

    4 / 4 results