Inflammatory Phenomena and Fibrosis in Androgenetic Alopecia

January 2010 in “ Springer eBooks ”

Ralph M. Trüeb

TLDR Hair loss in androgenetic alopecia may be due to ongoing tiny inflammation and tissue changes around hair follicles.

In this document, the authors discuss the role of inflammation and fibrosis in androgenetic alopecia, a condition characterized by hair follicle miniaturization and hair loss. They explain that while androgen metabolism plays a significant role in the development of this condition, simply blocking androgens has limited success in treating it. Histologic examination has shown that the miniaturization of hair follicles is often associated with perifollicular inflammatory phenomena and eventual fibrosis. This suggests that sustained microscopic follicular inflammation and connective tissue remodeling may contribute to permanent hair loss in androgenetic alopecia.

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