Hair Loss Evolving Into a Lifestyle and Metabolic Phenotype: A Hypothesis Exploring Oxidative Stress and Acquired Androgen Sensitivity Through Reactive Oxygen Species

    September 2026 in “ Journal of Hair Restoration and Regenerative Medicine ”
    Rajendra Singh J. Rajput
    Studysummary This study observed that hair loss in young adults is associated with several lifestyle factors, including oxidative stress and metabolic imbalances, despite normal androgen levels and a lack of family history in most cases.
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    Research cited in this study 42

    1. Arginine Metabolic Disruption Impairs Hair Regeneration via ROS-Mediated Inactivation of mTOR Signaling in Androgenetic Alopecia PubMed · 2025
    2. The Impact, Prevalence, and Association of Different Forms of Hair Loss Among Individuals With Anxiety Disorder: Systematic Review and Meta-Analysis Medicine · 2025
    3. The Association Between Alcohol Consumption and the Severity of Male Androgenic Alopecia in Chinese Participants: A Single-Center Cross-Sectional Study Journal of the American Academy of Dermatology · 2024
    4. Hair Loss Due to Pollution, Micro Metabolic Dysfunction, Epigenetics, and Role of Nutrients Brazilian Journal of Hair Health · 2024
    5. Androgenic Alopecia Is Associated With Higher Dietary Inflammatory Index And Lower Antioxidant Index Scores Frontiers in Nutrition · 2024
    6. Association Between PITX2 Polymorphism And Androgenetic Alopecia In The Indian Population Indian Journal of Dermatology Venereology and Leprology · 2024
    7. Homocysteine in Androgenetic Alopecia: A Case Control Study and Observational Experiments on Mice Journal of Cosmetic Dermatology · 2024
    8. Identification of VLDL as a Biomarker for Prewarning of Androgenic Alopecia Skin research and technology · 2024
    9. Methionine Dependence of Hair Maintenance in C57BL/6 Mice In Vivo · 2024
    10. The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology Skin appendage disorders · 2024
    11. Impaired Arginine Metabolism in Hair Follicles: A Potential Mechanism in Androgenetic Alopecia 2023
    12. Impact of Thyroid Dysfunction on Hair Disorders Cureus · 2023
    13. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    14. The Association Between Sugar-Sweetened Beverages and Male Pattern Hair Loss in Young Men Nutrients · 2023
    15. Evaluation of Stress in Hair Loss Through Biomarkers of Allostatic Load Hair transplant forum international · 2022
    16. Role of Smoking in Androgenetic Alopecia: A Systematic Review International Journal of Trichology · 2022
    17. Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia Experimental Dermatology · 2022
    18. Systematic Review and Meta-Analysis of the Association Between Metabolic Syndrome and Androgenetic Alopecia Acta dermato-venereologica · 2021
    19. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    20. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    21. Severity of Androgenetic Alopecia Associated with Poor Sleeping Habits and Carnivorous Eating and Junk Food Consumption—A Web-Based Investigation of Male Pattern Hair Loss in China Dermatologic Therapy · 2020
    22. Pediatric Androgenetic Alopecia: A Review Journal of The American Academy of Dermatology · 2019
    23. Do Kimchi and Cheonggukjang Probiotics as a Functional Food Improve Androgenetic Alopecia? A Clinical Pilot Study The World Journal of Men's Health · 2019
    24. Cholesterol Homeostasis: Links to Hair Follicle Biology and Hair Disorders Experimental Dermatology · 2019
    25. Relationship Between Working Hours And Probability To Take Alopecia Medicine Among Korean Male Workers: A 4-Year Follow-Up Study Annals of Occupational and Environmental Medicine · 2019
    26. The Role of Vitamins and Minerals in Hair Loss: A Review Dermatology and Therapy · 2018
    27. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    28. Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction Journal of Dermatological Science · 2017
    29. Lipid Profile in Patients with Androgenetic Alopecia: A Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2016
    30. Hair Follicle Characteristics as Early Marker of Type 2 Diabetes Medical Hypotheses · 2016
    31. Severity of Alopecia Predicts Coronary Changes and Arterial Stiffness in Untreated Hypertensive Men Journal of Clinical Hypertension · 2016
    32. Hair Loss Due to Electromagnetic Radiation from Overuse of Cell Phone Journal of cosmetology & trichology · 2016
    33. Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015
    34. Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells Journal of Biochemistry and Molecular Biology · 2013
    35. Consumption of a Low-Carbohydrate and High-Fat Diet Exaggerates Biotin Deficiency in Mice Nutrition · 2013
    36. Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling Proceedings of the National Academy of Sciences of the United States of America · 2013
    37. Androgenetic Alopecia and Risk of Coronary Artery Disease Indian Dermatology Online Journal · 2013
    38. Nutrition and Hair: The Role of Nutrients in Hair Health Dermatologic Clinics · 2012
    39. Committing to a Hairy Fate: Epigenetic Regulation of Hair Follicle Stem Cells Cell stem cell · 2011
    40. Early-Onset Androgenetic Alopecia and Endocrine Disruptors Journal of biological research · 2011
    41. Early Androgenetic Alopecia as a Marker of Insulin Resistance The Lancet · 2000
    42. Alopecia in Crash Dieters JAMA · 1976