TLDR VLDL could be an early warning sign for male pattern baldness.
The study "Identification of VLDL as a biomarker for prewarning of androgenic alopecia" used Mendelian randomization and Genome-wide association studies (GWAS) datasets from the UK Biobank and FinnGen to explore the relationship between androgenetic alopecia (AGA) and dyslipidemia. The study found that Valine and three very low-density lipoprotein (VLDL) subfractions (M_VLDL_C, M_VLDL_P, S_VLDL_FC) are positively associated with AGA risk. However, AGA had no effect on these four circulating metabolites. The study suggests that VLDL may contribute to the development of AGA by altering the vasculature, but further research is needed. The study was confined to patients of European origin, and additional validation in other populations is required.
15 citations,
October 2016 in “Journal of The European Academy of Dermatology and Venereology” People with hair loss have worse cholesterol levels, possibly linking hair loss to heart problems.
24 citations,
January 2013 in “Indian Dermatology Online Journal” Balding people may have higher heart disease risk.
January 2024 in “Journal of lipid research” Finasteride may lower cholesterol and slow heart disease progression.
15 citations,
October 2016 in “Journal of The European Academy of Dermatology and Venereology” People with hair loss have worse cholesterol levels, possibly linking hair loss to heart problems.
March 2020 in “Journal of the turkish academy of dermatology” There's no significant link between blood fat levels and male pattern baldness.
January 2014 in “S. Karger AG eBooks” Type 2 diabetes in youth is increasing, with high treatment failure rates and more severe than Type 1; certain drugs can lower lipid levels effectively with varying side effects, and apples may benefit heart health like statins but with fewer side effects.
March 2020 in “Journal of evolution of medical and dental sciences” Male pattern baldness, especially the vertex type, could be an early sign of cardiovascular risk factors like high cholesterol and diabetes.
