Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

    May 2022 in “ Frontiers in Cell and Developmental Biology ”
    Ying Lyu, Yejing Ge
    Studysummary This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 48

    1. Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis Cell Stem Cell · 2021
    2. Fibroblasts: Origins, Definitions, and Functions in Health and Disease Cell · 2021
    3. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020
    4. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    5. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    6. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019
    7. Stretching the Limits: From Homeostasis to Stem Cell Plasticity in Wound Healing and Cancer Nature Reviews Genetics · 2018
    8. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin Cell Reports · 2017
    9. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    10. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    11. Repeal And Replace: Adipocyte Regeneration In Wound Repair Cell Stem Cell · 2017
    12. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    13. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    14. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    15. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions Journal of Investigative Dermatology · 2015
    16. The Genetics of Human Skin Disease Cold Spring Harbor Perspectives in Medicine · 2014
    17. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4 Journal of Investigative Dermatology · 2014
    18. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    19. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013
    20. Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling Proceedings of the National Academy of Sciences of the United States of America · 2013
    21. Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair Developmental Cell · 2013
    22. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013
    23. Age-Associated Inflammation Inhibits Epidermal Stem Cell Function Genes & development · 2012
    24. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    25. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    26. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012
    27. The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity Nature · 2011
    28. Committing to a Hairy Fate: Epigenetic Regulation of Hair Follicle Stem Cells Cell stem cell · 2011
    29. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    30. TCF/Lef1 Activity Controls Establishment of Diverse Stem and Progenitor Cell Compartments in Mouse Epidermis The EMBO Journal · 2011
    31. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    32. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    33. Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice Reveal Hair Loss Abnormality ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    34. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    35. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    36. Hedgehog Signaling, Keratin 6 Induction, And Sebaceous Gland Morphogenesis American Journal Of Pathology · 2008
    37. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007
    38. The Cell-Surface Marker MTS24 Identifies a Novel Population of Follicular Keratinocytes With Characteristics of Progenitor Cells Development · 2006
    39. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    40. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    41. Conditional Telomerase Induction Causes Proliferation of Hair Follicle Stem Cells Nature · 2005
    42. Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling ˜The œAmerican journal of pathology · 2004
    43. Morpho-Regulation of Ectodermal Organs ˜The œAmerican journal of pathology · 2004
    44. Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors Development · 2002
    45. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001
    46. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    47. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    48. The Secret Life of the Hair Follicle Trends in genetics · 1992