Update on Platelet-Rich Plasma and Platelet-Rich Fibrin for Dermatologic Surgery: Addressing Knowns and Unknowns

    October 2024 in “ Dermatologic Surgery ”
    Sydney L. Proffer, Saranya P. Wyles, Amelia K. Hausauer
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    TLDR PRP and PRF show promise for hair growth but need more research for consistent and safe use.
    The document provides an update on the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in dermatologic surgery, emphasizing their growing application in hair restoration, particularly for androgenetic alopecia. PRP, which contains high concentrations of platelets, is shown to be effective in hair growth, especially when combined with minoxidil. However, there is inconsistency in PRP preparation and quality, and its use is off-label by the FDA. The document calls for more standardized preparation methods and large-scale trials to address variability in results. It also highlights safety concerns, such as a CDC investigation into HIV transmission during PRP microneedling. Overall, PRP and PRF are promising regenerative therapies, but further research is needed to optimize treatment protocols.
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