TLDR The review found that the way Platelet-Rich Plasma is made varies a lot, which can change the results of medical treatments.
The scoping review by Pachito et al. from December 2020 analyzed 39 studies to assess the variability in technical procedures for preparing and administering Platelet-Rich Plasma (PRP) and related products. The review found significant differences in PRP processing methods, which could affect clinical trial outcomes for various medical conditions. It highlighted the lack of standardization in PRP preparation, with variations in commercial kits, anticoagulants, activation methods, and centrifugation protocols impacting platelet, leukocyte, and growth factor concentrations. For instance, different commercial kits produced varying levels of growth factors, and anticoagulants like EDTA affected platelet morphology and viability. Activation methods and centrifugation protocols also influenced growth factor release and cell proliferation. The addition of certain substances to PRP could alter its characteristics, such as reducing tenocyte proliferation or increasing growth factor release. The review underscored the need for standardized PRP preparation protocols to optimize clinical outcomes, as the current variability in processing leads to inconsistent results. However, due to the lack of clinical trials comparing different PRP preparation methods, no definitive conclusions could be drawn about the best practices for PRP processing in terms of efficacy and safety.
44 citations,
February 2020 in “Expert Opinion on Biological Therapy” PRP, especially AA-PRP, can help improve hair growth in androgenetic alopecia.
58 citations,
January 2020 in “International Journal of Molecular Sciences” Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.
6 citations,
January 2018 in “Journal of Cutaneous and Aesthetic Surgery” ACD-A gives the highest platelet count for hair rejuvenation, but Sodium Citrate results in less contamination, making it higher quality.
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136 citations,
February 2017 in “International Journal of Molecular Sciences” PRP treatment improves hair growth, and the device used can affect results, with some being more effective.
August 2023 in “International journal of medical science and clinical research studies” PRP therapy helps heal pediatric surgical wounds faster and with fewer scars but needs more research for safety and cost.
February 2018 in “InTech eBooks” PRP therapy is effective for hair regrowth and improving hair quality with minimal side effects.
12 citations,
April 2015 in “InTech eBooks” Platelet Rich Plasma (PRP) shows promise for tissue repair and immune response, but more research is needed to fully understand it and optimize its use.
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May 2015 in “Hair transplant forum international” The article concludes that PRP might help with hair loss, but more detailed research is necessary.
2 citations,
June 2021 in “Cosmoderma” Platelet-rich plasma (PRP) shows promise in skin and hair treatments but results vary with preparation methods.
