Platelet-Rich Plasma for the Treatment of Alopecia: A Systematic Review and Meta-Analysis

    January 2023 in “ PubMed ”
    Mario Cruciani, Francesca Masiello, Ilaria Pati, Giuseppe Carlo Marano, Simonetta Pupella, Vincenzo De Angelis
    TLDR PRP might help with hair growth, but the evidence is weak.
    This systematic review and meta-analysis evaluated the efficacy of platelet-rich plasma (PRP) in treating androgenetic alopecia (AGA) and alopecia areata (AA) by analyzing 27 controlled trials involving 1,117 subjects. The results showed that PRP injections increased hair density compared to saline injections (MD, 25.6 hairs/cm²; 95% CI: 2.62-48.57) in AGA patients, but the evidence was rated as low quality due to inconsistency and risk of bias. For AA patients, the benefit of PRP compared to triamcinolone injections was unclear, with very low-quality evidence. No serious adverse events were reported. Overall, the evidence supporting PRP's benefit for alopecia treatment is limited and of low quality.
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