Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia

    Peixin Li, Yanfang Sun, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Yinjian Hua, Guohua Jiang
    TLDR The study created a new hair loss treatment paste that regrows hair faster and with fewer side effects than minoxidil alone.
    The study developed a treatment for androgenetic alopecia (AGA), a common hair loss condition, using a composite paste system. This system uses minoxidil-loaded nanoparticles and valproic acid, delivered through microchannels created in the skin by roller-microneedles. The paste is composed of carboxymethyl cellulose, hyaluronic acid, and polyvinylpyrrolidone. The combination of valproic acid, which stimulates hair follicle regrowth, and the microchannels created by the roller-microneedles, resulted in faster hair regeneration at a lower administration frequency in an AGA mouse model compared to using minoxidil alone. This method reduces the risk of infection from subcutaneous injection and significantly decreases the side effects of lower-dose minoxidil.
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