Development of Ethosomes for the Topical Treatment of Androgenic Alopecia: Ethanol Effect on Dutasteride Targeting to the Hair Follicles

    June 2025 in “ Pharmaceutics
    Jayanaraian F. M. Andrade, Rafael V. Rocho, Breno N. Matos, Geisa N. Barbalho, Kariane Mendes Nunes, Marcílio Cunha‐Filho, Guilherme M. Gelfuso, Taís Gratieri
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    TLDR Ethosomes with 30% ethanol effectively deliver dutasteride to hair follicles for treating hair loss.
    The study developed ethosomes with varying ethanol concentrations to enhance the delivery of dutasteride to hair follicles for treating androgenic alopecia. Ethosomes with 30% ethanol (ET30) were most effective, achieving a higher follicular targeting factor and improved drug release compared to controls. The presence of ethanol enhanced skin permeation and targeting to hair follicles, while minimizing systemic absorption and side effects. In vitro tests on porcine skin confirmed these findings, suggesting that ethanol-containing ethosomes could be a promising topical treatment for androgenic alopecia, though further research is needed to confirm clinical efficacy and safety.
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