Cellulose Nanocrystal-Stabilized Pickering Emulsion Gels as Vehicles for Follicular Delivery of Minoxidil

    Xuan Pang, Song Han, Kang Zheng, Jiang Liu, Xiaogang Wang, Shao‐Song Qian
    TLDR New gels using cellulose nanocrystals effectively deliver minoxidil to hair follicles, promoting hair regrowth.
    This study developed a novel minoxidil (MXD) Pickering emulsion gel for targeted delivery to hair follicles, leveraging deep eutectic solvents (DES), cellulose nanocrystals (CNC), and sodium carboxymethyl cellulose (CMC-Na). The DES significantly improved MXD solubility, facilitating the formation of stable Pickering emulsions with a droplet size of 679 nm. The MXD Pickering emulsion gel demonstrated enhanced rheological properties and stability, effectively promoting hair regrowth by upregulating hair growth factors. This innovative formulation offers a promising approach for treating androgenetic alopecia by targeting the dermal papilla within hair follicles.
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