Determination of Protonation State in Molecular Salt of Minoxidil and 2,4-Dihydroxybenzoic Acid Through a Combined Experimental and Theoretical Study: Influence of Proton Transfer on Biological Activities

September 2021 in “ Journal of molecular structure ”

Qi Wang, Zhongchang Sun, Danping Li, Kai Yang, Changjian Xie, Shujing Zhang, Liu Jiang, Kang Zheng, Qiuxiang Pang

minoxidil 2,4-dihydroxybenzoic acid hair growth molecular salt proton transfer monoclinic space group P21/c in vivo assessments mouse hair growth model pharmaceutical salts Rogaine

TLDR The MXD/24HA salt is more effective for hair growth than raw MXD.

In this study, a new molecular salt of minoxidil (MXD) and 2,4-dihydroxybenzoic acid (24HA) was synthesized and characterized, confirming proton transfer and crystallization in the monoclinic space group P21/c. In vivo assessments in a mouse hair growth model showed that the MXD/24HA salt is more effective in promoting hair growth than raw MXD, indicating its potential as a treatment for hair loss. This research offers a novel methodology for understanding structural and property differences in pharmaceutical salts.

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