Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application

    February 2021 in “ Journal of Pharmaceutical Sciences ”
    Arpar Ngampanya, Udomsak Udomnilobol, Pakawadee Sermsappasuk … Thomayant Prueksaritanont
    Studysummary This study suggests that the developed PBPK model effectively predicts pharmacokinetic and pharmacodynamic profiles of topical finasteride and minoxidil on the scalp, indicating potential broader applicability for other formulations.
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    Research cited in this study 11

    1. Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version Journal of Dermatology · 2018
    2. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    3. A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers International Journal of Clinical Pharmacology and Therapeutics · 2014
    4. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    5. Topical Formulations Containing Finasteride: Determination of Finasteride Penetration into Hair Follicles Using the Differential Stripping Technique Journal of Pharmaceutical Sciences · 2014
    6. Investigation of Drug Partition Property in Artificial Sebum International Journal of Pharmaceutics · 2007
    7. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    8. A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride Clinical Pharmacology & Therapeutics · 1998
    9. The Pharmacokinetics of 2.5- to 10-mg Oral Doses of Minoxidil in Healthy Volunteers The Journal of Clinical Pharmacology · 1989
    10. Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use Drugs · 1981
    11. Pharmacokinetic Studies of Minoxidil Clinical Pharmacology & Therapeutics · 1972

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    2. Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application Journal of Pharmaceutical Sciences · 2021
    3. Pharmacological Therapeutics in Androgenetic Alopecia Journal of The Korean Medical Association · 2020
    4. Hair Loss in Lichen Planopilaris and Frontal Fibrosing Alopecia: Not Always Irreversible Skin appendage disorders · 2020
    5. Characteristics of Korean Scalp Hair and Male Pattern Baldness Journal of The Korean Medical Association · 2013
    6. Finasteride Treatment of Patterned Hair Loss in Normoandrogenic Postmenopausal Women Dermatology · 2004
    7. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    8. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994