TLDR Minoxidil's crystal structure shows two different molecule shapes and nitrogen states.
The study detailed the crystal structure of Minoxidil, an antialopecia agent, revealing that it belonged to the space group P21 with specific cell dimensions. The research found two crystallographically independent molecules in an asymmetric unit, which adopted significantly different conformations. Additionally, the nitrogen atoms in the piperidine rings exhibited markedly different hybridization states in these molecules.
8 citations
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January 2011 in “Organic and Biomolecular Chemistry” Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.
25 citations
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August 2015 in “Molecules” Mimosine dipeptides are promising for treating hyperpigmentation and inflammation.
125 citations
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May 2019 in “Phytomedicine” Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.
April 2025 in “Journal of Advanced Pharmaceutical Technology amp Research” A mix of Morinda citrifolia fruit and Averrhoa bilimbi leaves boosts hair growth better than minoxidil.
2 citations
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January 2023 in “Pharmaceuticals” Natural products and phytochemicals may help with hair regrowth, but more research is needed.
