TLDR Different solvents change minoxidil crystal shapes and improve flowability.
The study explores the effects of different alcoholic solvents on the morphology of spherical crystals of minoxidil, a drug used to treat androgenetic alopecia. It highlights the formation of various spherical crystal aggregates, including the novel spherulite aggregates (SLA) produced in a n-butanol–ethyl acetate mixture. The addition of ethyl acetate alters the morphology and promotes agglomeration of spherulites. The research also examines the flowability and powder properties of SLA, noting a 15.8% reduction in the repose angle and a 24.7% decrease in the Hausner ratio. Additionally, a unique butterfly-shaped crystal of minoxidil is reported, which forms spontaneously in a homogeneous solution.
May 2024 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” Oral minoxidil 7.5 mg for hair loss increases heart rate but not blood pressure.
7 citations
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February 2019 in “Journal of Molecular Liquids” Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.
20 citations
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October 2018 in “Physics and chemistry of liquids” Minoxidil dissolves better in ethanol-water mixtures at different temperatures, with water playing a key role.
24 citations
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April 2011 in “Journal of Chemical & Engineering Data” Minoxidil dissolves best in methanol and least in water.
The research shows how certain drugs can form stable structures with polymers, which is important for making new pharmaceuticals.
The research found how certain drugs and polymers form stable complexes, which could help develop new pharmaceutical forms.
The research shows how certain drug molecules form stable structures with polymers, which could help create new drug forms.
16 citations
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July 1986 in “Dermatology” Using minoxidil lotion for hair regrowth in androgenetic alopecia has limited success and should be evaluated carefully.
8 citations
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March 2020 in “Aesthetic Plastic Surgery” Finasteride and minoxidil together safely and effectively increase hair growth and density for androgenetic alopecia.
