Effects of Solvents on Spherical Crystals of Minoxidil

September 2025 in “ Crystal Growth & Design ”

C. Geng, Jingtao Wang

minoxidil androgenetic alopecia spherulite aggregates n-butanol ethyl acetate spherical crystals Rogaine

TLDR Different solvents change minoxidil crystal shapes and improve flowability.

The study explores the effects of different alcoholic solvents on the morphology of spherical crystals of minoxidil, a drug used to treat androgenetic alopecia. It highlights the formation of various spherical crystal aggregates, including the novel spherulite aggregates (SLA) produced in a n-butanol–ethyl acetate mixture. The addition of ethyl acetate alters the morphology and promotes agglomeration of spherulites. The research also examines the flowability and powder properties of SLA, noting a 15.8% reduction in the repose angle and a 24.7% decrease in the Hausner ratio. Additionally, a unique butterfly-shaped crystal of minoxidil is reported, which forms spontaneously in a homogeneous solution.

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Research cited in this study

4 / 4 results

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research Oral Minoxidil 7.5 mg for Hair Loss Increases Heart Rate with No Change in Blood Pressure in 24-Hour Holter and 24-Hour Ambulatory Blood Pressure Monitoring

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Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

research Experimental and Computational Approaches for Measuring Minoxidil Solubility in Propylene Glycol and Water Mixtures at Different Temperatures

7 citations , February 2019 in “Journal of Molecular Liquids”

Minoxidil dissolves better in propylene glycol and water as temperature and propylene glycol amount increase.

research Solubility of Minoxidil in Binary Mixture of Ethanol and Water at Various Temperatures

20 citations , October 2018 in “Physics and chemistry of liquids”

Minoxidil dissolves better in ethanol-water mixtures at different temperatures, with water playing a key role.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from 278.15 to 333.15 K

24 citations , April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

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