Effects of Solvents on Spherical Crystals of Minoxidil

    September 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Chenwei Geng (22259301), Jingtao Wang (828021)
    TLDR Different solvents affect minoxidil crystal shapes, improving flowability and revealing a unique butterfly-shaped crystal.
    This study explores the effects of different alcoholic solvents on the morphology of minoxidil's spherical crystals, which are important for pharmaceutical manufacturing. The research introduces spherulite aggregates (SLA) formed in a mixture of n-butanol and ethyl acetate, noting that ethyl acetate influences their morphology and promotes agglomeration. The study highlights the significance of generating supersaturation in determining spherulite morphology. The flowability of SLA is improved, with a 15.8% reduction in the repose angle and a 24.7% decrease in the Hausner ratio. Additionally, a unique butterfly-shaped crystal of minoxidil is identified, which grows spontaneously in a homogeneous solution.
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