Effects of Solvents on Spherical Crystals of Minoxidil

    September 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Chenwei Geng (22259301), Jingtao Wang (828021)
    TLDR Different solvents affect minoxidil crystal shapes, improving flowability and revealing a unique butterfly-shaped crystal.
    This study explores the effects of different alcoholic solvents on the morphology of minoxidil's spherical crystals, which are important for pharmaceutical manufacturing. The research introduces spherulite aggregates (SLA) formed in a mixture of n-butanol and ethyl acetate, noting that ethyl acetate influences their morphology and promotes agglomeration. The study highlights the significance of generating supersaturation in determining spherulite morphology. The flowability of SLA is improved, with a 15.8% reduction in the repose angle and a 24.7% decrease in the Hausner ratio. Additionally, a unique butterfly-shaped crystal of minoxidil is identified, which grows spontaneously in a homogeneous solution.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Foam minoxidil with Tretinoin (Which Tretinoin Strength?)

      in Minoxidil  2 upvotes 6 days ago
      The conversation discusses using foam minoxidil with tretinoin cream for hair loss, with users sharing experiences on tretinoin strengths of 0.025% and 0.05%. Some users report irritation with higher tretinoin concentrations and note that foam minoxidil may be less effective than liquid.

      community 3,5 months of only topical minoxidil

      in Minoxidil  767 upvotes 6 days ago
      A 24-year-old reported new hair growth on temples after 3.5 months of using topical minoxidil without shedding. They plan to add finasteride to maintain progress, as minoxidil alone may not be enough long-term.

      community Minoxidil question

      in Minoxidil  41 upvotes 1 week ago
      Minoxidil is being questioned for its effects on surrounding hair when applied to a receding hairline. The user is concerned it might worsen the appearance by causing nearby hair to fall out.

    Similar Research

    5 / 1000+ results