Minoxidil/Salicylic Acid Hydrogel Formulated for Alopecia Treatment: Supramolecular Interactions Modulate Physicochemical Properties and Biological Activities

February 2024 in “ Journal of Molecular Structure ”

Jie Mi, Kang Zheng, Liu Jiang, Xuan Pang, Jianping Wang, Qi Wang, Zhongchang Sun, Bingji Li, Yanshan Cui, Shuliang Jiao, Qiuxiang Pang

minoxidil salicylic acid alopecia supramolecular hydrogel supramolecular chemistry physicochemical properties therapeutic efficacy X-ray crystallography Rogaine

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Salicylic acid →

Studysummary In this study, researchers developed a supramolecular hydrogel combining minoxidil and salicylic acid, finding that it accelerates hair growth and enhances hair follicle regeneration in vivo, suggesting its potential as an effective treatment for alopecia.

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The research paper presents a study on the development of a new topical formulation for alopecia treatment using minoxidil (MXD) and salicylic acid (SA) in a supramolecular hydrogel. The researchers used supramolecular chemistry to improve the physicochemical properties and therapeutic efficacy of MXD. The MXD/SA salt was prepared by slow solvent evaporation and characterized using various methods such as X-ray crystallography. The study found that the MXD/SA hydrogel showed improved properties and therapeutic effects for successful alopecia treatment. The research contributes to a comprehensive understanding of the supramolecular medicinal chemistry for MXD.

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