Minoxidil/Salicylic Acid Hydrogel Formulated for Alopecia Treatment: Supramolecular Interactions Modulate Physicochemical Properties and Biological Activities

February 2024 in “ Journal of Molecular Structure ”

Jie Mi, Kang Zheng, Liu Jiang, Xuan Pang, Jianping Wang, Qi Wang, Zhongchang Sun, Bingji Li, Yanshan Cui, Shuliang Jiao, Qiuxiang Pang

minoxidil salicylic acid alopecia supramolecular hydrogel supramolecular chemistry physicochemical properties therapeutic efficacy X-ray crystallography Rogaine

TLDR The new minoxidil and salicylic acid hydrogel improves alopecia treatment.

The research paper presents a study on the development of a new topical formulation for alopecia treatment using minoxidil (MXD) and salicylic acid (SA) in a supramolecular hydrogel. The researchers used supramolecular chemistry to improve the physicochemical properties and therapeutic efficacy of MXD. The MXD/SA salt was prepared by slow solvent evaporation and characterized using various methods such as X-ray crystallography. The study found that the MXD/SA hydrogel showed improved properties and therapeutic effects for successful alopecia treatment. The research contributes to a comprehensive understanding of the supramolecular medicinal chemistry for MXD.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

7 / 7 results

Hair Regrowth Boosting Via Minoxidil Cubosomes: Formulation Development, In Vivo Hair Regrowth Evaluation, Histopathological Examination, and Confocal Laser Microscopy Imaging

research Hair Regrowth Boosting Via Minoxidil Cubosomes: Formulation Development, In Vivo Hair Regrowth Evaluation, Histopathological Examination, and Confocal Laser Microscopy Imaging

January 2023 in “International Journal of Pharmaceutics”

A new version of minoxidil, a hair loss treatment, was made using nanotechnology. This version, called minoxidil cubosomes, works better and causes fewer skin reactions than the old version. It also penetrates and stays in the skin better, promoting hair regrowth. It's safe and could be a good alternative to current treatments.

research Minoxidil Multi-Component Crystals with Aromatic Carboxylic Acids: Theoretical Calculation and Structural Analysis

1 citations, April 2022 in “Crystal Growth & Design”

research Determination of Protonation State in Molecular Salt of Minoxidil and 2,4-Dihydroxybenzoic Acid Through a Combined Experimental and Theoretical Study: Influence of Proton Transfer on Biological Activities

12 citations, September 2021 in “Journal of molecular structure”

The MXD/24HA salt is more effective for hair growth than raw MXD.

research Minoxidil: A Comprehensive Review

16 citations, June 2021 in “Journal of Dermatological Treatment”

Minoxidil effectively treats hair loss, especially androgenetic alopecia, but needs more research for better understanding.

research Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application

4 citations, February 2021 in “Journal of Pharmaceutical Sciences”

The model can help predict how finasteride and minoxidil work when applied to the scalp.

Intestinal Permeability Study of Minoxidil: Assessment of Minoxidil as a High Permeability Reference Drug for Biopharmaceutics Classification

research Intestinal Permeability Study of Minoxidil: Assessment of Minoxidil as a High Permeability Reference Drug for Biopharmaceutics Classification

13 citations, January 2015 in “Molecular Pharmaceutics”

Minoxidil works well as a high permeability reference drug for biopharmaceutics classification.

research Attempted Construction of Minoxidil: Carboxylic Acid Cocrystals; 7 Salts and 1 Cocrystal Resulted

66 citations, February 2010 in “CrystEngComm”

Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.

Related Research

7 / 7 results

Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.

research Tretinoin Enhances Minoxidil Response in Androgenetic Alopecia Patients by Upregulating Follicular Sulfotransferase Enzymes

8 citations, April 2019 in “Dermatologic Therapy”

Tretinoin boosts minoxidil's effect on hair loss by increasing enzyme activity.

research The Use of Minoxidil in the Treatment of Male and Female Androgenetic Alopecia: A Story of More Than 30 Years

5 citations, January 2018 in “Italian journal of dermatology and venereology”

Minoxidil effectively stimulates hair growth in androgenetic alopecia.

Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

research Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

1 citations, January 2010

Mesotherapy is more effective than topical spray for female hair loss treatment.

A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations, August 2002 in “Journal of The American Academy of Dermatology”

5% minoxidil works better for hair growth and density, with minor irritation.

research Androgenetic Alopecia: Treatment Results with Topical Minoxidil

39 citations, March 1987 in “Journal of The American Academy of Dermatology”

Topical minoxidil is a safe and effective treatment for hair loss caused by androgenetic alopecia.

research Topical Minoxidil Therapy and Hair Regrowth

20 citations, February 1985 in “Archives of Dermatology”

Minoxidil helps hair regrowth, especially with more indeterminate hairs.