Hair Regrowth Boosting Via Minoxidil Cubosomes: Formulation Development, In Vivo Hair Regrowth Evaluation, Histopathological Examination, and Confocal Laser Microscopy Imaging

February 2023 in “ International Journal of Pharmaceutics ”

Amal Makhlouf, Tayseer Elnawawy

minoxidil minoxidil cubosomes nanotechnology hair regrowth skin reactions in vivo study penetration retention histopathological examination confocal laser microscopy Rogaine MXD-CUB

Studysummary In this study, the researchers developed minoxidil cubosomes using nanotechnology, which improved drug penetration in the skin, showed greater hair growth efficacy, and reduced adverse skin reactions compared to traditional minoxidil solutions.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study developed a new formulation of minoxidil, a treatment for hair loss, using nanotechnology. The optimized formulation, called minoxidil cubosomes (MXD-CUB), showed improved effectiveness and reduced skin reactions compared to traditional minoxidil solutions. In an in vivo study, the MXD-CUB formulation demonstrated a hair regrowth boosting effect, with better penetration and retention in the skin. The formulation was found to be safe and effective, suggesting it could be a promising alternative to current commercial formulations.

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Research cited in this study

18 / 18 results

research Development of Minoxidil-Loaded Double Emulsion PLGA Nanoparticles for the Treatment of Hair Loss

2 citations , May 2022 in “Journal of Industrial and Engineering Chemistry”

This study observed that minoxidil-loaded nanoparticles significantly enhanced skin penetration and hair regrowth in mice within three weeks, without ethanol and propylene glycol, suggesting they are a promising delivery method for treating hair loss.

Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

research Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

13 citations , September 2020 in “International Journal of Molecular Sciences”

This study found that combining platelet-rich plasma therapy with minoxidil was more effective in treating androgenetic alopecia in men than either treatment alone.

research Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages

130 citations , August 2020 in “Drug Design Development and Therapy”

This review discusses various nanoparticles used to enhance skin permeation and target delivery to skin organelles, but reports no new experimental results.

The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

research The Hydroxypropyl-β-Cyclodextrin-Minoxidil Inclusion Complex Improves the Cardiovascular and Proliferative Adverse Effects of Minoxidil in Male Rats: Implications in the Treatment of Alopecia

6 citations , May 2020 in “Pharmacology Research & Perspectives”

This study in rats found that a new hydroxypropyl-β-cyclodextrin formulation of minoxidil reduced the adverse cardiovascular and proliferative effects seen with traditional minoxidil solutions.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.

research Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

22 citations , March 2020 in “Cosmetics”

This review discusses the potential of nanotechnology-based formulations for delivering topical minoxidil to improve hair loss treatment outcomes and reports no new clinical results, urging further research into their benefits and safety considerations.

A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

research A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

22 citations , October 2019 in “Dermatologic Surgery”

This study found that platelet-rich plasma was effective for hair regrowth in women with androgenic alopecia, though less so than minoxidil, but it was associated with improved quality of life responses.

research The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern

36 citations , November 2018 in “American Journal of Clinical Dermatology”

This review discusses the significant burden of disease and psychosocial implications associated with alopecia, highlighting its comorbidities and the impact on quality of life despite being viewed traditionally as an aesthetic concern, but reports no clinical results.

research Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

27 citations , September 2018 in “Medicines”

This study reported that oleic acid-based nanovesicles improve follicular delivery and reduce side effects of minoxidil compared to traditional MXD lotions.

research Evaluation of Animal Models Suitable for Hair Research and Regeneration

3 citations , May 2018 in “InTech eBooks”

This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.

research Review of Quality of Life Studies in Women with Alopecia

58 citations , January 2018 in “International Journal of Women's Dermatology”

This review discusses the psychological impact of alopecia on women and reports no new clinical findings, highlighting the effect on self-esteem and quality of life.

A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors

research A Hypothetical Pathogenesis Model for Androgenic Alopecia: Clarifying the Dihydrotestosterone Paradox and Rate-Limiting Recovery Factors

30 citations , December 2017 in “Medical Hypotheses”

This review evaluates dihydrotestosterone's role in androgenic alopecia and proposes a model suggesting that chronic scalp tension and inflammation contribute to hair follicle miniaturization, identifying fibrosis, calcification, and tension as treatment targets.

research Formulation and Optimization of Transfersome Containing Minoxidil and Caffeine

32 citations , December 2017 in “Journal of Drug Delivery Science and Technology”

This study found that co-delivery of minoxidil and caffeine in transfersomes with an optimized polysorbate formulation enhanced hair length and weight in vivo.

Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

research Characterization of Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex in Aqueous Alginate Gel Useful for Alopecia Management: Efficacy Evaluation in Male Rats

19 citations , October 2017 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that the MXD/HP-β-CD GEL formulation promoted greater hair growth and improved gene expression related to hair growth in male rats compared to MXD solution or control groups.

The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research New Ethanol and Propylene Glycol Free Gel Formulations Containing a Minoxidil-Methyl-Beta-Cyclodextrin Complex as Promising Tools for Alopecia Treatment

18 citations , March 2014 in “Drug Development and Industrial Pharmacy”

This study evaluated new aqueous gel formulations of minoxidil without irritants and found that the calcium alginate gel showed the best performance in terms of drug release and skin permeation.