The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

    June 2022 in “ Pharmaceutics
    Milica Markovic, Moran Zur, Sapir Garsiani, Daniel Porat, Sandra Cvijić, Gordon L. Amidon, Arik Dahan
    TLDR Minoxidil's absorption is too variable for it to be a reliable reference drug.
    The study investigates the intestinal absorption and biopharmaceutical characterization of minoxidil, focusing on paracellular transport using in-silico, in-vitro, and in-vivo methods. It finds that minoxidil's permeability is pH-independent and significantly influenced by tight junction modifiers, with quercetin decreasing and sodium decanoate increasing permeability. Approximately 15% of minoxidil is absorbed paracellularly, primarily in the proximal intestine. Due to the variability introduced by paracellular transport, minoxidil is unsuitable as a Biopharmaceutics Classification System (BCS) reference drug for low/high permeability classification.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 1000+ results

      community Should I add oral minoxidil right now?

      in Minoxidil  69 upvotes 17 hours ago
      The user is considering adding oral minoxidil to their current hair loss treatment, which includes dutasteride and occasional finasteride, due to concerns about hair thinning and potential shedding. They are unsure if starting both treatments simultaneously could worsen shedding or if oral minoxidil might be beneficial.

      community Stoped minoxidil 5 weeks ago and still bloated

      in Minoxidil  75 upvotes 2 days ago
      The user stopped using minoxidil 5 weeks ago due to facial swelling, which initially subsided but then returned. Despite a healthy lifestyle and normal test results, the user is concerned about the persistent bloating.

      community Duoxidil / Dutasteride/ Minoxidil

      in Minoxidil  82 upvotes 1 week ago
      The conversation discusses a user's positive experience with hair loss treatments, including Duoxidil, oral Dutasteride, oral Minoxidil, and biotin, noting no side effects and effective results. The user plans to start a new cycle of Dutasteride and PRP sessions.

    Related Research

    1 / 1 results