Breaking Bald: Unraveling the Mysteries of Hair Loss and Modern Treatments

June 2024 in “ IP Indian journal of clinical and experimental dermatology ”

Karishma M. Rathi, Priyanka Pingat, Ritesh P. Bhole, S. S. Mishra, Surat Singh

TLDR Hair loss has many causes and treatments, but future research aims for better solutions.

This review article explores the complex issue of alopecia, or hair loss, affecting millions globally. It examines various causes, including genetics, hormonal imbalances, nutritional deficiencies, stress, and medical conditions, with a special note on COVID-19-induced telogen effluvium. Current treatments like minoxidil, finasteride, hair transplants, laser therapy, and platelet-rich plasma therapy are discussed, highlighting their effectiveness and limitations. Future research is focused on innovative solutions such as gene therapies, stem cell interventions, and advanced delivery methods using nanotechnology. The review also underscores the psychological impact of hair loss and the need for holistic treatment approaches to improve patient well-being.

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research Compliance to Topical Minoxidil and Reasons for Discontinuation Among Patients With Androgenetic Alopecia

April 2023 in “Dermatology and therapy”

research A Novel Hair Restoration Technology Counteracts Androgenic Hair Loss and Promotes Hair Growth in a Blinded Clinical Trial

1 citations , January 2023 in “Journal of Clinical Medicine”

A new hair restoration technology was found to effectively increase hair thickness, density, and growth, while reducing hair loss and improving scalp health, with no side effects.

research Aging of Hair Follicle Stem Cells and Their Niches

2 citations , November 2022 in “Journal of Biochemistry and Molecular Biology”

Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.

research Hair Loss and Telogen Effluvium Related to COVID-19: The Potential Implication of Adipose-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma as Regenerative Strategies

3 citations , August 2022 in “International Journal of Molecular Sciences”

research Characteristics of Hair Loss After COVID-19: A Systematic Scoping Review

12 citations , July 2022 in “Journal of Cosmetic Dermatology”

COVID-19 patients may experience temporary hair loss, mainly in women, which is likely reversible.

research Organic Hair Transplantation: A New Concept in Hair Transplantation

July 2022 in “Plastic surgery and modern techniques”

Using stem cell-enriched fat injections before hair transplant surgery can result in less hair loss and thicker hair.

research Injectable Platelet Rich Fibrin Therapy for Androgenetic Alopecia: A Series of 15 Cases

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research Effect of Coffee Berry Extract on Anti-Aging for Skin and Hair: In Vitro Approach

8 citations , June 2022 in “Cosmetics”

Coffee berry extract may help slow skin aging and prevent hair loss.

research Efficacy of Acupuncture and Moxibustion in Alopecia: A Narrative Review

June 2022 in “Frontiers in Medicine”

Acupuncture and moxibustion may help treat hair loss, but more research is needed.

research The Psychological Consequences of Androgenetic Alopecia: A Systematic Review

1 citations , April 2022 in “Journal of Cosmetic Dermatology”

research Hair Growth-Promoting Activities of Glycosaminoglycans Extracted from the Tunics of Ascidian (Halocynthia Roretzi)

3 citations , March 2022 in “Polymers”

Substances from Ascidian tunics might help treat hair loss as effectively as Minoxidil.

research A Systematic Review of Acute Telogen Effluvium, a Harrowing Post-COVID-19 Manifestation

25 citations , December 2021 in “Journal of Medical Virology”

COVID-19 can cause a type of hair loss that usually starts 74 days after infection, affecting mostly women, but most patients eventually recover.

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30 citations , October 2021 in “Journal of The American Academy of Dermatology”

Hair transplantation can effectively restore hair in balding areas.

research Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms

3 citations , June 2021 in “Cosmetics”

A mix of sulforaphane, L-menthol, and dexpanthenol could help increase hair growth and reduce hair loss.

research Usefulness of PRP Therapy in Androgenic Alopecia

June 2021 in “European journal of medical and health sciences”

research Application of Ethanol Extracts From Alnus Sibirica Fisch. ex Turcz in Hair Growth Promotion

8 citations , June 2021 in “Frontiers in Bioengineering and Biotechnology”

Extracts from Alnus sibirica and oregonin may help with hair growth and prevent hair loss.

research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations , March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

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research Practice Pattern and Use of Serum Peptide Formulation in Patients with Alopecia: Results of an Opinion Survey Among Dermatologists in India

December 2020 in “International Journal of Research in Dermatology”

Many dermatologists in India find serum peptide formulations effective for treating hair loss.

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11 citations , September 2020 in “Dermatologic therapy”

The document concludes that mesotherapy can be effective for skin and hair treatments, but more research is needed to confirm its safety and effectiveness.

research Clinical Study to Evaluate the Efficacy and Safety of a Hair Serum Product in Healthy Adult Male and Female Volunteers with Hair Fall

14 citations , September 2020 in “Clinical, cosmetic and investigational dermatology”

The hair serum significantly improved hair growth and reduced hair fall without causing any skin issues.

research Platelet-Rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-Controlled Pilot Study

8 citations , July 2020 in “Acta dermato-venereologica”

research Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal?

29 citations , March 2020 in “Stem Cells Translational Medicine”

Fully regenerating human hair follicles not yet achieved.

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7 citations , January 2020 in “International Journal of Molecular Sciences”

Low-frequency electromagnetic fields can boost molecules related to hair growth in human skin cells.

research Stem Cell Secretome as a New Booster for Regenerative Medicine

54 citations , August 2019 in “Bioscience trends”

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

research Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles by β-Catenin Activation and Related Cell Cycle Molecules

7 citations , July 2019 in “International Journal of Molecular Sciences”

PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.

research Determination of Follicular Direction and Preparation of Micrograft Holes for Hair Transplantation

January 2019 in “Srpski Arhiv Za Celokupno Lekarstvo”

The technique improved hair transplant success and patient satisfaction by matching hair growth direction.

research Physicochemical Characterization and Evaluation of Castor Oil (R. communis) for Hair Biocosmetics

2 citations , January 2019 in “American Journal of Applied Chemistry”

Castor oil is suitable for use in hair care products.

research Is Skin Microneedling a Good Alternative Method for Various Skin Defects Removal

23 citations , September 2018 in “Dermatologic Therapy”

Microneedling is a safe and effective way to improve various skin conditions with minimal side effects.

research A Proprietary Herbal Extract Against Hair Loss in Androgenetic Alopecia and Telogen Effluvium: A Placebo-Controlled, Single-Blind, Clinical-Instrumental Study

1 citations , June 2018 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

The herbal extract was found to effectively reduce and prevent hair loss without any side effects.

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1 citations , March 2018 in “Cureus”

Scrotal rejuvenation treats aging-related changes in men's scrotum using methods like medication, hair transplantation, and surgery.

research Human Umbilical Cord Blood Mesenchymal Stem Cells Engineered to Overexpress Growth Factors Accelerate Outcomes in Hair Growth

21 citations , January 2018 in “The Korean Journal of Physiology and Pharmacology”

Modified stem cells from umbilical cord blood can make hair grow faster.

research Ethnopharmacological Survey of Home Remedies Used for Treatment of Hair and Scalp and Their Methods of Preparation in the West Bank, Palestine

22 citations , July 2017 in “BMC complementary and alternative medicine”

Natural remedies for hair and scalp issues are still widely used in Palestine.

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June 2017 in “Experimental and Therapeutic Medicine”

The anti-CXCL4 antibody helps mice grow hair faster and prevents hair loss.

research The Success of Thread-Embedding Therapy in Generating Hair Regrowth in Mice Points to Its Possible Effect in Humans

20 citations , December 2015 in “Journal of Pharmacopuncture”

Thread-embedding therapy helped hair grow back in mice and might do the same in humans.

research Effect of Ethanol Extract of Plant Mixture on Hair Regeneration in Human Dermal Papilla Cells and C57BL/6J Mice

4 citations , December 2015 in “Journal of Medicinal Plants Research”

A plant mixture extract helped grow hair by boosting cell growth and growth factors while blocking a hair loss-related enzyme.

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8 citations , January 2015 in “Scars, burns & healing”

Hair transplantation effectively treats burn scar alopecia, improving self-esteem and confidence.

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86 citations , September 2014 in “Journal of The American Academy of Dermatology”

To diagnose hair loss, use a systematic approach including history, exams, and tests.

research Alteration of Skin Properties with Autologous Dermal Fibroblasts

67 citations , May 2014 in “International Journal of Molecular Sciences”

Using your own skin cells can help repair aging skin and promote hair growth.

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

66 citations , April 2014 in “Journal of Dermatological Treatment”

Finasteride and dutasteride effectively treat hair loss, but may cause side effects like sexual dysfunction and depression.

research The Biology of Hair Diversity

47 citations , March 2013 in “International Journal of Cosmetic Science”

Hair diversity is influenced by complex genetics and environmental factors, requiring more research for practical solutions.

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations , February 2013 in “PLOS ONE”

6-Gingerol, found in ginger, may slow down hair growth and could be used for hair removal.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations , September 2004 in “Journal of Investigative Dermatology”

Hair loss causes stress and affects mental health; treatment and support needed.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Molecular Genetic and Endocrine Mechanisms of Hair Growth

51 citations , January 2003 in “Hormone Research in Paediatrics”

Hormones and their receptors, especially androgens, play a key role in hair growth and disorders like baldness.