Biotransformation of Cacumen Platycladi Extract by Lactiplantibacillus Plantarum CCFM1348 Promotes Hair Growth in Mice

    Xin Tang, Tongtong Zhang, Botao Wang, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Wei Chen, Shumao Cui
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    TLDR Biotransformed Cacumen platycladi extract promotes hair growth in mice.
    The study investigates the effects of Cacumen platycladi (CP) extract fermented by Lactiplantibacillus plantarum CCFM1348 on hair growth in mice. The fermented CP, referred to as postbiotics, and a combination of live bacteria with nonfermented CP, referred to as synbiotics, were found to promote hair growth more effectively than nonfermented CP. This effect is attributed to the upregulation of the Wnt/β-catenin signaling pathway, which is crucial for hair follicle development, as well as increased expression of vascular endothelial growth factor and a decreased BAX/Bcl2 ratio, indicating reduced apoptosis. These findings suggest that fermented CP could be a potential treatment for hair loss.
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