Evaluation of the Treatment Effect of Aloe Vera Fermentation in Burn Injury Healing Using a Rat Model
January 2019
in “
Mediators of inflammation
”
Aloe vera oxidative stress markers eosinophils fibroblasts vessel proliferation scab shedding hair growth proinflammatory factors TNF-α IL-1β anti-inflammatory factor IL-4 gut microbiota Firmicutes probiotic bacteria Lactobacillus Bacteroidetes Prevotella Blautia tumor necrosis factor alpha interleukin-1 beta interleukin-4 probiotics
TLDR Aloe vera fermentation helps heal burns faster by reducing inflammation and changing gut bacteria.
The study evaluated the effects of Aloe vera fermentation on burn injury healing in a rat model. The results showed that Aloe vera fermentation significantly reduced oxidative stress markers and inhibited the growth of various pathogens in vitro. In vivo, it increased the presence of eosinophils and fibroblasts, reduced vessel proliferation, and accelerated healing by promoting scab shedding and hair growth by the 14th day. Aloe vera fermentation also decreased the production of proinflammatory factors TNF-α and IL-1β, while increasing the anti-inflammatory factor IL-4 in animal serum. Additionally, high-throughput sequencing revealed that Aloe vera fermentation altered the gut microbiota, increasing the percentage of Firmicutes and probiotic bacteria like Lactobacillus, while decreasing Bacteroidetes and pathogens such as Prevotella and Blautia. The study concluded that Aloe vera fermentation significantly enhances burn injury healing by reducing inflammation and modifying gut microbiota.
