Evaluation of Cacumen Platycladi Extract for Hair Loss Prevention: Mechanisms, Efficacy, and Clinical Application

January 2026 in “ Cosmetics ”

Xuedong Bai, Yuchen Liu, Hong-Yun Zhao, Yi-zhou LUO, Lijun Xu, Feng Luo

Cacumen Platycladi extract 5α-reductase antioxidant human dermal papilla cells PI3K/Akt/mTOR pathway VEGF COL17 CPE Platycladus orientalis

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Vascular Endothelial Growth Factor →

platycladus orientalis →

Studysummary This study reported that Cacumen Platycladi extract significantly reduced hair loss and increased hair density in a 12-week clinical trial, suggesting it may be a safe and effective natural treatment. Our plain-language summary of this paper — not a Tressless recommendation.

The study evaluated the efficacy of Cacumen Platycladi extract (CPE) in preventing hair loss, highlighting its potential as a natural treatment. CPE, derived from Platycladus orientalis leaves, was shown to inhibit 5α-reductase activity, enhance antioxidant capacity in human dermal papilla cells, and activate the PI3K/Akt/mTOR pathway, promoting VEGF and COL17 expression. A 12-week clinical trial demonstrated that CPE significantly reduced hair loss and increased hair density compared to a placebo, with no adverse effects, supporting its use as a safe and effective hair loss prevention alternative.

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