Aging of Hair Follicle Stem Cells and Their Niche: Mechanisms and Regenerative Therapeutic Strategies

    Siqi Xu, Jiming Guo, Ying Kang … Bo Jia
    Studysummary This review discusses the aging process of hair follicle stem cells and their niche, focusing on degradation mechanisms and potential therapeutic strategies, but it reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 54

    1. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway Stem Cell Research & Therapy · 2025
    2. Enhancing Hair Regrowth Using Rapamycin-Primed Mesenchymal Stem Cell-Derived Exosomes Theranostics · 2025
    3. Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia Acta Biomaterialia · 2025
    4. Erythrocyte Extracellular Vesicles Integrate into Hair and Skin to Maintain Homeostasis Journal of Extracellular Vesicles · 2025
    5. Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging Aging Cell · 2025
    6. Gas-Propelled Anti-Hair Follicle Aging Microneedle Patch for the Treatment of Androgenetic Alopecia Journal of Controlled Release · 2025
    7. Restoration of Hair Follicle Inductive Properties by Depletion of Senescent Cells Aging Cell · 2024
    8. Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging Journal of Advanced Research · 2024
    9. Irradiation-Induced Hair Graying in Mice: An Experimental Model to Evaluate the Effectiveness of Interventions Targeting Oxidative Stress, DNA Damage Prevention, and Cellular Senescence GeroScience · 2024
    10. Modeling of Solar UV-Induced Photodamage on the Hair Follicles in Human Skin Organoids Journal of tissue engineering · 2024
    11. The Homing of Exogenous Hair Follicle Mesenchymal Stem Cells Into Hair Follicle Niches JCI Insight · 2023
    12. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    13. Single Cell Analysis of Transcriptome and Open Chromatin Reveals the Dynamics of Hair Follicle Stem Cell Aging Frontiers in Aging · 2023
    14. Signaling by Senescent Melanocytes Hyperactivates Hair Growth Nature · 2023
    15. Regulation of Adult Stem Cell Quiescence and Its Functions in the Maintenance of Tissue Integrity Nature Reviews Molecular Cell Biology · 2023
    16. Microenvironmental Reprogramming of Human Dermal Papilla Cells for Hair Follicle Tissue Engineering Acta Biomaterialia · 2022
    17. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    18. Bioprinting of Hair Follicle Germs for Hair Regenerative Medicine Acta biomaterialia · 2022
    19. Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying Cell discovery · 2022
    20. Emerging Role of Dermal White Adipose Tissue in Modulating Hair Follicle Development During Aging Frontiers in Cell and Developmental Biology · 2021
    21. Tissue Mechanics in Haired Murine Skin: Potential Implications for Skin Aging Frontiers in Cell and Developmental Biology · 2021
    22. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    23. Hair Follicle Germs Containing Vascular Endothelial Cells for Hair Regenerative Medicine Scientific Reports · 2021
    24. Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration Journal of Advanced Research · 2020
    25. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    26. Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells Nature · 2020
    27. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    28. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    29. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    30. Long-Term Intravital Imaging of the Cornea, Skin, and Hair Follicle by Multiphoton Microscope Methods in molecular biology · 2019
    31. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018
    32. Caloric Restriction Promotes Structural and Metabolic Changes in the Skin Cell Reports · 2017
    33. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    34. Directed Elimination of Senescent Cells by Inhibition of BCL-W and BCL-XL Nature communications · 2016
    35. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations Cell · 2015
    36. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    37. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    38. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    39. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    40. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    41. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    42. Hair Restoration Surgery: The State of the Art Aesthetic Surgery Journal · 2012
    43. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    44. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    45. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    46. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    47. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    48. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    49. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    50. Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile Involving Catalase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    51. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    52. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    53. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    54. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000