Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging

    March 2025 in “ Aging Cell ”
    Yang Wang, Jian Yang, Yue Luo … Zhi‐Xiong Jim Xiao
    Studysummary In this study on mice, elevated IGF-1 levels in the skin were linked to premature aging of hair follicles, but interventions like reducing IGF-1 or using senolytic treatments helped restore stem cell health and counteract aging effects.
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    Research cited in this study 10

    1. Recent Omics Advances In Hair Aging Biology And Hair Biomarkers Analysis Ageing Research Reviews · 2023
    2. Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways International journal of molecular sciences · 2023
    3. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Journal of Dermatological Science · 2017
    4. Stress-Induced Premature Senescence of Dermal Papilla Cells Compromises Hair Follicle Epithelial-Mesenchymal Interaction Journal of Dermatological Science · 2017
    5. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    6. A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis Journal of Visualized Experiments · 2015
    7. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    8. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    9. APCDD1 Is a Novel Wnt Inhibitor Mutated in Hereditary Hypotrichosis Simplex Nature · 2010
    10. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005