Imbalanced Redox Dynamics Induce Fibroblast Senescence Leading to Impaired Stem Cell Pools and Skin Aging
March 2025
in “
Free Radical Biology and Medicine
”
redox dynamics fibroblast senescence stem cell pools skin aging oxidative stress mitochondrial dysfunction reactive oxygen species ROS redox-sensitive transcription factor JunB p16INK4A IGF-1 senescence-associated secretory phenotype SASP collagen degradation skin tensile strength redox-imbalanced senescent fibroblasts collagen skin health
Studysummary This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.
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