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This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.

HA-iMSC-EVs can improve skin aging by boosting cell growth and restoring collagen and elastin.

In this study, aged mice showed better regenerative skin outcomes than young mice, linked to a specific fibroblast subpopulation and enhanced signaling interactions that promote regeneration. EREG treatment improved young mice's skin regeneration, suggesting potential for scarless therapies.

This study found that different stressors causing premature senescence in fibroblasts resulted in distinct changes in lipid profiles, particularly sphingolipids, which may affect the behavior of senescent skin cells.

Senescent fibroblasts can help start tumors in normal skin cells.