Regulation of the Lipidome and Lipid Metabolism in Prematurely Senescent Human Dermal Fibroblasts

The study "517 Regulation of the lipidome and lipid metabolism in prematurely senescent human dermal fibroblasts" investigates the impact of environmental factors on skin aging, focusing on the role of senescent cells and their lipid profiles. The research found that senescent cells, which accumulate in aged skin due to prolonged exposure to stressors like UV radiation and pollution, negatively affect their microenvironment and contribute to age-related tissue decline. Using a UHPLC triple quadrupole MS/MS method, the study confirmed an increase of lysophospholipids in stress-induced premature senescent (SIPS) fibroblasts and revealed that phospholipids are not the only senescence regulated lipids. The study also found that fibroblasts develop different lipid profiles depending on the type of stress-induced senescence, with a noted upregulation of sphingolipid degradation pathway’s enzymes in doxorubicin treated fibroblasts. These senescence-related changes to sphingolipids and immunomodulatory phospholipids may contribute to the fate and signaling of senescent cells in the skin.