Study on the Mechanism of Cadmium Chloride Pollution Accelerating Skin Tissue Metabolism Disorder, Aging and Inhibiting Hair Regeneration

This study investigated the effects of cadmium chloride (CdCl2) pollution on skin metabolism, aging, and hair regeneration using 18 C57BL/6 mice divided into three groups: Control, Low-dose, and High-dose, with 6 mice in each. The mice were administered different concentrations of CdCl2 daily for one month. Non-targeted metabolomics analysis revealed 29 different metabolites in the Low-dose group and 39 in the High-dose group, with a decrease in metabolites such as lysophospholipids, fatty acids, bile acids, and amino acid compounds compared to the Control group. Immunofluorescence assays indicated that higher concentrations of CdCl2 resulted in more pronounced inhibition of skin cell proliferation, increased apoptosis, and significant damage to hair follicle stem cells. The study concludes that cadmium chloride pollution can lead to skin metabolic disorders, accelerate aging, and inhibit hair regeneration.