Senescence-Induced Reparative Fibroblasts Enable Scarless Wound Healing in Aged Murine Skin
April 2025
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
senescence fibroblasts scarless wound healing hair follicle collagen fibers Prss35+Fib epithelial cells macrophages T cell subpopulations PTN signaling EREG signaling spatial transcriptomics upper dermis regenerative niche scarless healing hair follicles collagen fibroblast epithelial macrophage T cells dermis
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary In this study, aged mice showed better regenerative skin outcomes than young mice, linked to a specific fibroblast subpopulation and enhanced signaling interactions that promote regeneration. EREG treatment improved young mice's skin regeneration, suggesting potential for scarless therapies.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
Read the full study on biorxiv.org →