Senescent Fibroblasts Secretome Promotes Tumoral Initiation of Normal Human Keratinocytes Through Cellular Activation, Enhanced Migration, and ECM Remodeling

    June 2010 in “ European Journal of Cancer Supplements ”
    Albin Pourtier, Nicolas Malaquin, Chantal Vercamer, M. Chwastinyak, F Pinet, Corinne Abbadie
    TLDR Senescent fibroblasts can help start tumors in normal skin cells.
    The study investigated the role of the secretome of senescent fibroblasts in promoting tumor initiation in normal human keratinocytes. It was found that the secretome led to cellular activation, enhanced migration, and extracellular matrix (ECM) remodeling, which are processes that can contribute to tumor development. This research highlighted the potential impact of senescent fibroblasts on the tumorigenic behavior of nearby cells, suggesting that the secretome of these fibroblasts could play a significant role in the early stages of cancer development.
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