Investigating the Mechanisms Underlying Age-Related Dysfunctions in Skin and Hair Follicle Regeneration

    May 2020
    Wisoo Shin
    TLDR Senescence and genomic instability in fibroblasts contribute to hair loss and impaired skin regeneration with age.
    The study investigated age-related dysfunctions in skin and hair follicle regeneration, focusing on the role of mesenchymal stem cells and fibroblasts. It identified Rspondin3 as a key modulator in hair follicle regeneration and found that senescence drives hair follicle mesenchymal aging, contributing to hair loss. Aged mice showed impaired wound-induced hair neogenesis due to an excess of senescent fibroblasts. Genomic instability was shown to impair hair follicle regeneration, mimicking natural aging. The research highlighted the importance of fibroblast heterogeneity in maintaining skin function and provided insights into skin aging and stem cell research.
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