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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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5 / 1000+ resultsresearch Senescent Fibroblasts Secretome Promotes Tumoral Initiation of Normal Human Keratinocytes Through Cellular Activation, Enhanced Migration, and ECM Remodeling
Senescent fibroblasts can help start tumors in normal skin cells.
research Regulation of the Lipidome and Lipid Metabolism in Prematurely Senescent Human Dermal Fibroblasts
Aging skin cells change their lipid profiles due to stress, affecting skin health.
research Investigating the Mechanisms Underlying Age-Related Dysfunctions in Skin and Hair Follicle Regeneration
Senescence and genomic instability in fibroblasts contribute to hair loss and impaired skin regeneration with age.
research Cellular and Molecular Mechanisms of Repair in Acute and Chronic Wound Healing
Acute wounds heal well, but chronic wounds struggle due to ongoing inflammation and poor tissue repair.
research Update on Melasma—Part I: Pathogenesis
Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.
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5 / 35 resultscommunity Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year
A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
community Got my Oleic fatty acid they used in Korean study. Fuck you mice!
Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.
community Anti-oxidants that reverse hairloss?
Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.
community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory
DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.
community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.
ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.