Epigenetic Orchestration of RNA m6A Methylation in Wound Healing and Post-Wound Events
July 2025
in “
International Journal of Biological Sciences
”
N6-methyladenosine m6A methylation keratinocyte migration fibroblast activation macrophage polarization stem cell differentiation diabetic wounds burn injuries oxidative stress autophagy deficiency pathological scarring dysfunctional appendage regeneration epitranscriptome-targeted therapies chronic wound management skin regeneration RNA methylation wound healing tissue remodeling RNA processes healing impairment advanced techniques
Studysummary This review highlights that the RNA modification N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.
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