Epigenetic Orchestration of RNA m6A Methylation in Wound Healing and Post-Wound Events
July 2025
in “
International Journal of Biological Sciences
”
N6-methyladenosine m6A methylation keratinocyte migration fibroblast activation macrophage polarization stem cell differentiation diabetic wounds burn injuries oxidative stress autophagy deficiency pathological scarring dysfunctional appendage regeneration epitranscriptome-targeted therapies chronic wound management skin regeneration RNA methylation wound healing tissue remodeling RNA processes healing impairment advanced techniques
TLDR m<sup>6</sup>A methylation is crucial for proper wound healing and tissue repair.
This document discusses the role of N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation in wound healing and tissue remodeling, highlighting its importance in regulating RNA processes that affect keratinocyte migration, fibroblast activation, macrophage polarization, and stem cell differentiation. Dysregulated m<sup>6</sup>A dynamics are linked to impaired healing in diabetic wounds and burn injuries, contributing to oxidative stress, autophagy deficiency, pathological scarring, and dysfunctional appendage regeneration. Despite advances, the understanding of m<sup>6</sup>A's spatiotemporal regulation remains incomplete. The review emphasizes the need for future research using advanced techniques to develop epitranscriptome-targeted therapies for chronic wound management and skin regeneration.
