RNA Modifications: Molecular Orchestrators of Wound Healing

This review explores the role of macrophage subsets in adult cutaneous wound healing and emphasizes their potential for therapeutic targeting, but reports no new experimental results.

This review highlights that the RNA modification N⁶-methyladenosine (m⁶A) plays a crucial role in regulating wound healing and tissue remodeling, with dysregulation contributing to complications in chronic wounds, such as diabetic ulcers and burn injuries, through mechanisms like impaired angiogenesis and increased oxidative stress.

This review highlights single-cell sequencing's role in understanding macrophages' diverse functions and subtypes in skin wound healing, emphasizing macrophages' importance in tissue restoration and identifying key genes involved in the process.

This study identified a new role for IL-4Ra-induced oxidative metabolism in wound macrophages, essential for balancing inflammatory response and promoting pro-fibrotic repair, suggesting a target for fibrosis prevention.

This thesis found that inhibiting IL-17 and IL-23 improved chronic wound healing in obese, diabetic mice by promoting a pro-healing macrophage phenotype, while ST2 signaling was also necessary for effective wound healing.