RNA Modifications: Molecular Orchestrators of Wound Healing

January 2026 in “ Burns & Trauma ”

Xiuying Guo, Lele Liu, Junqi Yang, Yuhe Dai, Qianbo Zhang, Rifang Gu, Min Tan, Ming Tang, Xuqiang Nie

RNA modifications wound healing skin wounds macrophage polarization tissue regeneration topical hydrogels exosome-based therapies biomarker strategies

TLDR RNA modifications help heal wounds and could lead to new treatments.

This review explores the role of RNA modifications in wound healing, focusing on skin wounds, bone fractures, and corneal injuries. It highlights the mechanistic roles of four key RNA modifications and their impact on processes like macrophage polarization and tissue regeneration. The review identifies translational opportunities for treating burns and trauma, suggesting therapeutic strategies such as topical hydrogels and exosome-based therapies. It also discusses the design of clinical trials and biomarker strategies to translate preclinical findings into patient care, while acknowledging methodological limitations and knowledge gaps.

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