Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

The review highlights the role of bioactive biopolymers such as alginate, chitosan, hyaluronic acid, and collagen in diabetic wound healing, emphasizing the importance of their structural properties in determining bioactivity. These biopolymers possess bioadhesive, antimicrobial, anti-inflammatory, and proangiogenic properties, making them promising for wound healing. Alginate's molecular characteristics influence its healing effects, while chitosan's antimicrobial and anti-inflammatory properties are linked to its structure. Hyaluronic acid's molecular weight affects its anti-inflammatory and angiogenic properties, and collagen's structural attributes influence its mechanical resilience and cellular modulation. The review stresses the need for further research to optimize the synthesis and application of these materials by understanding their structure-function relationships.