Dynamic Hyaluronic Acid Hydrogels for Regulating Inflammation, Angiogenesis, and Metabolism to Heal Diabetic Wounds

December 2024 in “ ACS Applied Materials & Interfaces ”

Yanzheng Chen, Li Wang, Fangrui Ning, Chang Du, Ming-Sheng Chen, Chuanliang Feng, Chang‐Ming Dong

hyaluronic acid hydrogel inflammation angiogenesis metabolism M1-to-M2 polarization inflammatory cytokines reactive oxygen species H2S release Zn2+ regulation neovascularization re-epithelization collagen-I deposition hair follicle regeneration HA hydrogels ROS zinc regulation sulfur release

Studysummary In this study, dynamic hyaluronic acid hydrogels with properties like injectability and controlled degradation were developed to enhance healing and remodeling of diabetic wounds, achieving effects such as inflammation reduction, increased angiogenesis, and neovascularization, leading to complete wound healing.

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