An ROS-Scavenging Treg-Recruiting Hydrogel Patch for Diabetic Wound Healing

February 2024 in “ Advanced Functional Materials ”

Mengjie Qu, Wei Xu, Xingwu Zhou, Fan Tang, Qian Chen, Xia Zhang, Xiaofeng Bai, Zhi Yong Li, Xing Jiang, Qianming Chen

TLDR The hydrogel patch helps heal diabetic wounds by releasing a healing agent in response to harmful molecules and improving skin regeneration.

The research paper discusses the development of an ROS-scavenging Tregs-recruiting hydrogel patch for diabetic wound healing. The patch is designed to sequentially release C─C motif chemokine 22 (CCL22) triggered by the reactive oxygen species (ROS) in the diabetic wound bed. The hydrogel patch, prepared by crosslinking gelatin with an ROS cleavable linker along with CCL22 (RSG-CCL22), has physical properties suitable for skin regeneration. The ROS scavenging feature of the RSG suppresses the differentiation of T helper 17 (Th17) cells and protects the recruited Tregs from apoptosis and oxidative stress. This maximizes their function in accelerating wound closure and promoting hair follicle regeneration in a diabetic full-thickness skin defect mouse model. The study suggests a new therapeutic strategy for tissue regeneration and wound repair through effective recruitment of functional Tregs via ROS-triggered on-demand delivery.

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