An ROS-Scavenging Treg-Recruiting Hydrogel Patch for Diabetic Wound Healing
February 2024
in “
Advanced Functional Materials
”
ROS-scavenging Tregs-recruiting hydrogel patch C─C motif chemokine 22 CCL22 reactive oxygen species ROS gelatin ROS cleavable linker T helper 17 cells Th17 cells apoptosis oxidative stress wound closure hair follicle regeneration diabetic full-thickness skin defect tissue regeneration wound repair Tregs hydrogel wound healing hair regeneration skin defect tissue repair
Studysummary This study reported that a newly developed hydrogel patch, designed to recruit regulatory T cells through ROS-triggered release of CCL22, improved wound healing and hair follicle regeneration in a diabetic mouse model by scavenging ROS, thereby protecting Tregs and suppressing Th17 cells.
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