Multifunctional And Immunoregulatory Microenvironment-Responsive Hydrogel For Whole Course Management Of Infected Diabetic Wounds

August 2024 in “ Chemical Engineering Journal ”

Zhenyu Luo, Xiaoxue Fu, Hua Jiang, Weikun Meng, Shue Jin, Yongrui Cai, Ze Du, Ping Song, An-Jing Chen, Li Li, Peifang Li, Jiali Chen, Weinan Zeng, Zongke Zhou

ATAN-Met hydrogel re-epithelialization neurovascular regeneration hair follicle regeneration mesenchymal stem cells macrophage polarization Hippo pathway TNF pathway

Studysummary This study found that a microenvironment-responsive ATAN-Met hydrogel system improved infective diabetic wound healing by enhancing re-epithelialization, neurovascular and hair follicle regeneration, and exhibited antibacterial and immunoregulatory effects, activated beneficial pathways, and responded to glucose/ROS for drug release.

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