Multifunctional And Immunoregulatory Microenvironment-Responsive Hydrogel For Whole Course Management Of Infected Diabetic Wounds

August 2024 in “ Chemical Engineering Journal ”

Zhenyu Luo, Xiaoxue Fu, Hua Jiang, Weikun Meng, Shue Jin, Yongrui Cai, Ze Du, Ping Song, An-Jing Chen, Li Li, Peifang Li, Jiali Chen, Weinan Zeng, Zongke Zhou

ATAN-Met hydrogel re-epithelialization neurovascular regeneration hair follicle regeneration mesenchymal stem cells macrophage polarization Hippo pathway TNF pathway

Studysummary This study found that a microenvironment-responsive ATAN-Met hydrogel system improved infective diabetic wound healing by enhancing re-epithelialization, neurovascular and hair follicle regeneration, and exhibited antibacterial and immunoregulatory effects, activated beneficial pathways, and responded to glucose/ROS for drug release.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study presents a multifunctional ATAN-Met hydrogel system designed to enhance the healing of infective diabetic wounds by promoting re-epithelialization, neurovascular and hair follicle regeneration, and providing antibacterial and immunoregulatory effects. The hydrogel, which responds to high glucose and reactive oxygen species for drug release, demonstrated self-healing and wearable properties. It effectively recruited mesenchymal stem cells, facilitated their interaction with neural cells, regulated macrophage polarization, and modulated the wound microenvironment. The system activated the Hippo pathway and inhibited the TNF pathway, improving wound healing outcomes. These findings suggest that the ATAN-Met hydrogel holds significant promise for managing infective diabetic wounds.

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