Drug Conjugates Crosslinked Bioresponsive Hydrogel for Combination Therapy of Diabetic Wound

The study presents a novel combination therapy using a bioresponsive hydrogel (bFGF-HSPP-NAC) for diabetic wound healing. This hydrogel incorporates basic fibroblast growth factor (bFGF) and N-acetylcysteine (NAC) to address the oxidative stress in diabetic wounds. The hydrogel's design allows for controlled drug release in response to oxidative stress, initially releasing NAC to reduce oxidative damage, followed by bFGF to promote tissue regeneration. The results show that this approach significantly enhances re-epithelialization, collagen deposition, hair follicle regeneration, and neovascularization, indicating its potential for effective diabetic wound treatment.